Beilstein J. Org. Chem.2016,12, 2136–2144, doi:10.3762/bjoc.12.203
analogue.
Keywords: base-pairing; base-pair mismatch; DNAfunctionalization; DNA templates; dynamic combinatorial chemistry; D-threoninol based scaffolds; Introduction
The well-defined duplex structure, self-assembling by base-pair recognition, and the accessibility by solid-phase synthesis make DNA
functionalized by imine or thioester formation. In principle this concept allows dynamic DNAfunctionalization with all kind of functional or recognition units at positions that were modified with the threoninol deoxyribose analogous by solid phase synthesis. As proof of principle the 13mer oligonucleotide
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Graphical Abstract
Figure 1:
Template-directed dynamic chemistry assay for the attachment of modified nucleobase monomers to an ...